{"id":1426,"date":"2020-12-16T13:18:00","date_gmt":"2020-12-16T16:18:00","guid":{"rendered":"https:\/\/revista.suryamkt.com.br\/?p=1426"},"modified":"2022-04-06T15:05:00","modified_gmt":"2022-04-06T18:05:00","slug":"carvedilol-as-primary-prophylaxis-for-gastric-variceal-bleeding-in-portal-hypertension-model-in-rats","status":"publish","type":"post","link":"https:\/\/revistaabcd.org.br\/pt-br\/carvedilol-as-primary-prophylaxis-for-gastric-variceal-bleeding-in-portal-hypertension-model-in-rats\/","title":{"rendered":"CARVEDILOL AS PRIMARY PROPHYLAXIS FOR GASTRIC VARICEAL BLEEDING IN PORTAL HYPERTENSION MODEL IN RATS"},"content":{"rendered":"<h2 class=\"wp-block-heading\">Background:<\/h2>\n\n\n\n<p>Portal hypertension (PH) can be measured indirectly through a hepatic vein pressure gradient greater than 5 mmHg. Cirrhosis is the leading cause for PH and can present as complications ascites, hepatic dysfunction, renal dysfunction, and esophagogastric varices, characterizing gastropathy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Aim:<\/h2>\n\n\n\n<p>To evaluate the use of carvedilol as primary prophylaxis in the development of collateral circulation in rats submitted to the partial portal vein ligament (PPVL) model.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Method:<\/h2>\n\n\n\n<p>This is a combined qualitative and quantitative experimental study in which 32 Wistar rats were divided into four groups (8 animals in each): group I - cirrhosis + carvedilol (PPVL + C); group II - cirrhosis + vehicle (PPVL); group III - control + carvedilol (SO-sham-operated + C); group IV - control + vehicle (SO-sham-operated). After seven days of the surgical procedure (PPVL or sham), carvedilol (10 mg\/kg) or vehicle (1 mL normal saline) were administered to the respective groups daily for seven days.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Results:<\/h2>\n\n\n\n<p>The histological analysis showed no hepatic alteration in any group and a decrease in edema and vasodilatation in the PPVL + C group. The laboratory evaluation of liver function did not show a statistically significant change between the groups.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Conclusion:<\/h2>\n\n\n\n<p>Carvedilol was shown to have a positive effect on gastric varices without significant adverse effects.<\/p>","protected":false},"excerpt":{"rendered":"<p>Background: Portal hypertension (PH) can be measured indirectly through a hepatic vein pressure gradient greater than 5 mmHg. Cirrhosis is the leading cause for PH and can present as complications ascites, hepatic dysfunction, renal dysfunction, and esophagogastric varices, characterizing gastropathy. Aim: To evaluate the use of carvedilol as primary prophylaxis in the development of collateral [&hellip;]<\/p>","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_lmt_disableupdate":"no","_lmt_disable":"","footnotes":""},"categories":[9],"tags":[366,367,111],"acf":[],"modified_by":"Roni","_links":{"self":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts\/1426"}],"collection":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/comments?post=1426"}],"version-history":[{"count":2,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts\/1426\/revisions"}],"predecessor-version":[{"id":1496,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts\/1426\/revisions\/1496"}],"wp:attachment":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/media?parent=1426"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/categories?post=1426"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/tags?post=1426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}