Portal hypertension (PH) can be measured indirectly through a hepatic vein pressure gradient greater than 5 mmHg. Cirrhosis is the leading cause for PH and can present as complications ascites, hepatic dysfunction, renal dysfunction, and esophagogastric varices, characterizing gastropathy.<\/p>\n\n\n\n
To evaluate the use of carvedilol as primary prophylaxis in the development of collateral circulation in rats submitted to the partial portal vein ligament (PPVL) model.<\/p>\n\n\n\n
This is a combined qualitative and quantitative experimental study in which 32 Wistar rats were divided into four groups (8 animals in each): group I - cirrhosis + carvedilol (PPVL + C); group II - cirrhosis + vehicle (PPVL); group III - control + carvedilol (SO-sham-operated + C); group IV - control + vehicle (SO-sham-operated). After seven days of the surgical procedure (PPVL or sham), carvedilol (10 mg\/kg) or vehicle (1 mL normal saline) were administered to the respective groups daily for seven days.<\/p>\n\n\n\n
The histological analysis showed no hepatic alteration in any group and a decrease in edema and vasodilatation in the PPVL + C group. The laboratory evaluation of liver function did not show a statistically significant change between the groups.<\/p>\n\n\n\n
Carvedilol was shown to have a positive effect on gastric varices without significant adverse effects.<\/p>","protected":false},"excerpt":{"rendered":"
Background: Portal hypertension (PH) can be measured indirectly through a hepatic vein pressure gradient greater than 5 mmHg. Cirrhosis is the leading cause for PH and can present as complications ascites, hepatic dysfunction, renal dysfunction, and esophagogastric varices, characterizing gastropathy. Aim: To evaluate the use of carvedilol as primary prophylaxis in the development of collateral […]<\/p>","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_lmt_disableupdate":"no","_lmt_disable":"","footnotes":""},"categories":[9],"tags":[366,367,111],"class_list":["post-1426","post","type-post","status-publish","format-standard","hentry","category-original-article","tag-beta-adrenergic-antagonists","tag-gastropathy","tag-portal-hypertension"],"acf":{"authors":[{"author_name":" Andressa de Souza BERTOLDI ","orcid_id":" http:\/\/orcid.org\/0000-0002-6810-7619"},{"author_name":" Camila Roginski GUETTER ","orcid_id":" http:\/\/orcid.org\/0000-0002-7918-4580"},{"author_name":" Gabriel Antonio COLTRO ","orcid_id":" http:\/\/orcid.org\/0000-0001-6030-6392"},{"author_name":" Larissa Maria VOSGERAU ","orcid_id":" http:\/\/orcid.org\/0000-0002-3403-7528"},{"author_name":" Laura Maria Viscardi BRIGHENTI ","orcid_id":" http:\/\/orcid.org\/0000-0002-1764-6022"},{"author_name":" Nat\u00e1lia Izycki FAUAT ","orcid_id":" http:\/\/orcid.org\/0000-0003-3765-4123"},{"author_name":" Fernando Bermudez KUBRUSLY ","orcid_id":" http:\/\/orcid.org\/0000-0002-5045-9237"},{"author_name":" Camila Aparecida Moraes MARQUES ","orcid_id":" http:\/\/orcid.org\/0000-0001-5121-922X"},{"author_name":" Luiz Fernando KUBRUSLY ","orcid_id":" http:\/\/orcid.org\/0000-0002-6546-9841"}],"doi":"10.1590\/0102-672020200003e1525","buttons":{"pdf_-_en":1427,"pdf_-_pt":1428,"external_link":"https:\/\/www.scielo.br\/j\/abcd\/a\/9wDc7C7TxMpDZFrLFHBGtsy\/?lang=en","external_link_pt":"https:\/\/www.scielo.br\/j\/abcd\/a\/9wDc7C7TxMpDZFrLFHBGtsy\/?lang=pt","full_text":"","jats_xml":""},"volume_and_issue":{"article-volume":"2020 - vol. 33","article-issue":"Issue 3"}},"modified_by":null,"_links":{"self":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts\/1426","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/comments?post=1426"}],"version-history":[{"count":0,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts\/1426\/revisions"}],"wp:attachment":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/media?parent=1426"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/categories?post=1426"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/tags?post=1426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}