{"id":1514,"date":"2020-12-18T12:22:00","date_gmt":"2020-12-18T15:22:00","guid":{"rendered":"https:\/\/revistaabcd.org.br\/?p=1514"},"modified":"2022-04-06T12:40:26","modified_gmt":"2022-04-06T15:40:26","slug":"risk-factors-for-post-liver-transplant-biliary-complications-in-the-absence-of-arterial-complications","status":"publish","type":"post","link":"https:\/\/revistaabcd.org.br\/pt-br\/risk-factors-for-post-liver-transplant-biliary-complications-in-the-absence-of-arterial-complications\/","title":{"rendered":"RISK FACTORS FOR POST-LIVER TRANSPLANT BILIARY COMPLICATIONS IN THE ABSENCE OF ARTERIAL COMPLICATIONS"},"content":{"rendered":"<h2 class=\"wp-block-heading\">Background<\/h2>\n\n\n\n<p>- Biliary complications (BC) represent the most frequent complication after liver transplantation, up to 34% of cases.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Aim:<\/h2>\n\n\n\n<p>To identify modifiable risk factors to biliary complications after liver transplantation, essential to decrease morbidity.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Method:<\/h2>\n\n\n\n<p>Clinical data, anatomical characteristics of recipient and donors, and transplant operation features of 306 transplants with full arterial patency were collected to identify risk factors associated with BC.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Results:<\/h2>\n\n\n\n<p>BC occurred in 22.9% after 126 days (median) post-transplantation. In univariate analyses group 1 (without BC, n=236) and group 2 patients (with BC, n=70) did not differ on their general characteristics. BC were related to recipient age under 40y (p=0.029), CMV infection (p=0.021), biliary disease as transplant indication (p=0.018), lower pre-transplant INR (p=0.009), and bile duct diameter &lt;3 mm (p=0.033). CMV infections occurred sooner in patients with postoperative biliary complications vs. control (p=0.07). In a multivariate analysis, only CMV infection, lower INR, and shorter bile duct diameter correlated with BC. Positive CMV antigenemia correlated with biliary complications, even when titers lied below the treatment threshold.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Conclusions:<\/h2>\n\n\n\n<p>Biliary complications after liver transplantation correlated with low recipient INR before operation, bile duct diameter &lt;3 mm, and positive antigenemia for CMV or disease manifestation. As the only modifiable risk factor, routine preemptive CMV inhibition is suggested to diminish biliary morbidity after liver transplant.<\/p>\n\n\n\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>Background - Biliary complications (BC) represent the most frequent complication after liver transplantation, up to 34% of cases. Aim: To identify modifiable risk factors to biliary complications after liver transplantation, essential to decrease morbidity. Method: Clinical data, anatomical characteristics of recipient and donors, and transplant operation features of 306 transplants with full arterial patency were [&hellip;]<\/p>","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[9],"tags":[373,372,82],"class_list":["post-1514","post","type-post","status-publish","format-standard","hentry","category-original-article","tag-bile-ducts","tag-cytomegalovirus-infections","tag-liver-transplantation"],"acf":[],"modified_by":null,"_links":{"self":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts\/1514"}],"collection":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/comments?post=1514"}],"version-history":[{"count":0,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts\/1514\/revisions"}],"wp:attachment":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/media?parent=1514"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/categories?post=1514"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/tags?post=1514"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}