- Biliary complications (BC) represent the most frequent complication after liver transplantation, up to 34% of cases.<\/p>\n\n\n\n
To identify modifiable risk factors to biliary complications after liver transplantation, essential to decrease morbidity.<\/p>\n\n\n\n
Clinical data, anatomical characteristics of recipient and donors, and transplant operation features of 306 transplants with full arterial patency were collected to identify risk factors associated with BC.<\/p>\n\n\n\n
BC occurred in 22.9% after 126 days (median) post-transplantation. In univariate analyses group 1 (without BC, n=236) and group 2 patients (with BC, n=70) did not differ on their general characteristics. BC were related to recipient age under 40y (p=0.029), CMV infection (p=0.021), biliary disease as transplant indication (p=0.018), lower pre-transplant INR (p=0.009), and bile duct diameter <3 mm (p=0.033). CMV infections occurred sooner in patients with postoperative biliary complications vs. control (p=0.07). In a multivariate analysis, only CMV infection, lower INR, and shorter bile duct diameter correlated with BC. Positive CMV antigenemia correlated with biliary complications, even when titers lied below the treatment threshold.<\/p>\n\n\n\n
Biliary complications after liver transplantation correlated with low recipient INR before operation, bile duct diameter <3 mm, and positive antigenemia for CMV or disease manifestation. As the only modifiable risk factor, routine preemptive CMV inhibition is suggested to diminish biliary morbidity after liver transplant.<\/p>\n\n\n\n
<\/p>","protected":false},"excerpt":{"rendered":"
Background - Biliary complications (BC) represent the most frequent complication after liver transplantation, up to 34% of cases. Aim: To identify modifiable risk factors to biliary complications after liver transplantation, essential to decrease morbidity. Method: Clinical data, anatomical characteristics of recipient and donors, and transplant operation features of 306 transplants with full arterial patency were […]<\/p>","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[9],"tags":[373,372,82],"class_list":["post-1514","post","type-post","status-publish","format-standard","hentry","category-original-article","tag-bile-ducts","tag-cytomegalovirus-infections","tag-liver-transplantation"],"acf":{"authors":[{"author_name":"Agnaldo Soares LIMA","orcid_id":"http:\/\/orcid.org\/0000-0001-6421-3062"},{"author_name":"B\u00e1rbara Buitrago PEREIRA","orcid_id":"http:\/\/orcid.org\/0000-0003-3403-5722"},{"author_name":"Sven JUNGMANN","orcid_id":"http:\/\/orcid.org\/0000-0002-0553-9780"},{"author_name":"Carla Jorge MACHADO","orcid_id":"http:\/\/orcid.org\/0000-0002-6871-0709"},{"author_name":"Maria Isabel Toulson Davison CORREIA","orcid_id":"http:\/\/orcid.org\/0000-0002-3503-4302"}],"doi":"10.1590\/0102-672020200003e1541","buttons":{"pdf_-_en":1515,"pdf_-_pt":1516,"external_link":"https:\/\/www.scielo.br\/j\/abcd\/a\/JY3BmJHDScHpf8HY4HTppHn\/?lang=en","external_link_pt":"https:\/\/www.scielo.br\/j\/abcd\/a\/JY3BmJHDScHpf8HY4HTppHn\/?lang=pt","full_text":"","jats_xml":""},"volume_and_issue":{"article-volume":"2020 - vol. 33","article-issue":"Issue 3"}},"modified_by":null,"_links":{"self":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts\/1514","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/comments?post=1514"}],"version-history":[{"count":0,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts\/1514\/revisions"}],"wp:attachment":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/media?parent=1514"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/categories?post=1514"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/tags?post=1514"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}