Enteroendocrine L cells can be found in the entire gastrointestinal tract and their incretins act on glycemic control and metabolic homeostasis. Patients with severe obesity and type 2 diabetes mellitus may have lower density of L cells in the proximal intestine.<\/p>\n\n\n\n
This study aimed to analyze the density of L cells in the segments of the small intestine in the late postoperative of Roux-en-Y gastric bypass in diabetic patients with standardization of 60 cm in both loops, alimentary and biliopancreatic.<\/p>\n\n\n\n
Immunohistochemistry analysis assays were made from intestinal biopsies in three segments: gastrointestinal anastomosis (GIA= Point A), enteroenteral anastomosis (EEA= Point B= 60 cm distal to the GIA) and 60 cm distal to the enteroenteral anastomosis (Point C).<\/p>\n\n\n\n
A higher density of L cells immunostaining the glucagon-1 peptide was observed in the distal portion (Point C) when compared to the more proximal portions (Points A and B).<\/p>\n\n\n\n
The concentration of L cells is higher 60 cm distal to enteroenteral anastomosis when comparing to proximal segments and may explain the difference in intestinal lumen sensitization and enterohormonal response after Roux-en-Y gastric bypass.<\/p>","protected":false},"excerpt":{"rendered":"
BACKGROUND: Enteroendocrine L cells can be found in the entire gastrointestinal tract and their incretins act on glycemic control and metabolic homeostasis. Patients with severe obesity and type 2 diabetes mellitus may have lower density of L cells in the proximal intestine. AIMS: This study aimed to analyze the density of L cells in the […]<\/p>","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[9],"tags":[173,44,151,131,1140,174],"class_list":["post-4147","post","type-post","status-publish","format-standard","hentry","category-original-article","tag-diabetes-mellitus","tag-gastric-bypass","tag-glucagon-like-peptide-1","tag-immunohistochemistry","tag-l-cell","tag-type-2"],"acf":{"authors":[{"author_name":"Priscila Costa Estabile","orcid_id":"http:\/\/orcid.org\/0000-0003-3911-7866"},{"author_name":"Marco Aur\u00e9lio Santo","orcid_id":"http:\/\/orcid.org\/0000-0002-7813-6210"},{"author_name":"Eduardo Guimar\u00e3es Horneaux de Moura","orcid_id":"http:\/\/orcid.org\/0000-0002-8023-3722"},{"author_name":"Rog\u00e9rio Kuga","orcid_id":"http:\/\/orcid.org\/0000-0001-8925-1946"},{"author_name":"Priscila Caproni","orcid_id":"http:\/\/orcid.org\/0000-0002-6427-193X"},{"author_name":"Roberto de Cleva","orcid_id":"http:\/\/orcid.org\/0000-0001-8673-9014"},{"author_name":"Filippe Camarotto Mota","orcid_id":"http:\/\/orcid.org\/0000-0003-3508-6345"},{"author_name":"F\u00e1bio Quirillo Mill\u00e9o","orcid_id":"http:\/\/orcid.org\/0000-0002-3438-3156"},{"author_name":"Roberto Ferreira Artoni","orcid_id":"http:\/\/orcid.org\/0000-0002-2528-9846"}],"doi":"10.1590\/0102-672020220002e1681","buttons":{"pdf_-_en":4148,"pdf_-_pt":"","external_link":"https:\/\/www.scielo.br\/j\/abcd\/a\/pNfpxQDv4wQTyTnDccZpBZv\/?lang=en","external_link_pt":"","full_text":"","jats_xml":""},"volume_and_issue":{"article-volume":"2022 - vol. 35","article-issue":"Issue 1"}},"modified_by":null,"_links":{"self":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts\/4147","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/comments?post=4147"}],"version-history":[{"count":0,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts\/4147\/revisions"}],"wp:attachment":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/media?parent=4147"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/categories?post=4147"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/tags?post=4147"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}