{"id":5037,"date":"2014-09-01T10:54:38","date_gmt":"2014-09-01T13:54:38","guid":{"rendered":"https:\/\/revistaabcd.org.br\/?p=5037"},"modified":"2023-11-01T11:16:46","modified_gmt":"2023-11-01T14:16:46","slug":"importance-of-biopsies-and-histological-evaluation-in-patients-with-chronic-diarrhea-and-normal-colonoscopies","status":"publish","type":"post","link":"https:\/\/revistaabcd.org.br\/pt-br\/importance-of-biopsies-and-histological-evaluation-in-patients-with-chronic-diarrhea-and-normal-colonoscopies\/","title":{"rendered":"Importance of biopsies and histological evaluation in patients with chronic diarrhea and normal colonoscopies"},"content":{"rendered":"<h2>BACKGROUND:<\/h2>\n<p>In patients with chronic diarrhea, colonoscopy may identify inflammatory causes or some occult disease, and also can show a normal mucosa. Serial biopsies of intestinal mucosa can be useful for a differential diagnosis, and to modify the treatment.<\/p>\n<h2>AIM:<\/h2>\n<p>To evaluate whether the biopsies performed in patients with chronic diarrhea and a normal colonoscopy contribute to the differential diagnosis and alter the therapeutic approach.<\/p>\n<h2>METHODS:<\/h2>\n<p>A descriptive, retrospective and cross-sectional study using a computerized database was done<i>.<\/i>\u00a0Patients with chronic diarrhea and a normal colonoscopy underwent serial biopsies of the terminal ileum, ascending colon and rectum.<\/p>\n<h2>RESULTS:<\/h2>\n<p>From 398 records, 214 were excluded. Of the 184 patients enrolled, 91 showed histological changes: 40% nonspecific inflammation; 5.18% lymphocytic inflammation, 10.37% eosinophilic inflammation; 39.26% lymphoid hyperplasia; 2.22% collagenous colitis; 2.22% melanosis; and 0.74% pseudomelanose. The sites with the largest number of changes were the terminal ileum and right colon.<\/p>\n<h2>CONCLUSIONS:<\/h2>\n<p>Serial biopsies in patients with chronic diarrhea and normal colonoscopy identified changes in almost 50% of cases and 22% of these cases may had modified the treatment after identification of collagenous, lymphocytic and eosinophilic colitis.<\/p>","protected":false},"excerpt":{"rendered":"<p>BACKGROUND: In patients with chronic diarrhea, colonoscopy may identify inflammatory causes or some occult disease, and also can show a normal mucosa. Serial biopsies of intestinal mucosa can be useful for a differential diagnosis, and to modify the treatment. AIM: To evaluate whether the biopsies performed in patients with chronic diarrhea and a normal colonoscopy [&hellip;]<\/p>","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_lmt_disableupdate":"no","_lmt_disable":"","footnotes":""},"categories":[9],"tags":[1130,1295,294],"class_list":["post-5037","post","type-post","status-publish","format-standard","hentry","category-original-article","tag-biopsy","tag-collagenous-colitis","tag-colonoscopy"],"acf":[],"modified_by":null,"_links":{"self":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts\/5037"}],"collection":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/comments?post=5037"}],"version-history":[{"count":0,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts\/5037\/revisions"}],"wp:attachment":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/media?parent=5037"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/categories?post=5037"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/tags?post=5037"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}