{"id":6433,"date":"2026-04-14T12:11:36","date_gmt":"2026-04-14T15:11:36","guid":{"rendered":"https:\/\/revistaabcd.org.br\/?p=6433"},"modified":"2026-04-14T12:11:36","modified_gmt":"2026-04-14T15:11:36","slug":"gastric-neuroendocrine-tumors-a-comprehensive-analysis-of-clinicopathological-characteristics-and-survival-outcomes-from-a-reference-center","status":"publish","type":"post","link":"https:\/\/revistaabcd.org.br\/pt-br\/gastric-neuroendocrine-tumors-a-comprehensive-analysis-of-clinicopathological-characteristics-and-survival-outcomes-from-a-reference-center\/","title":{"rendered":"Gastric neuroendocrine tumors: a comprehensive analysis of clinicopathological characteristics and survival outcomes from a reference center"},"content":{"rendered":"<h2><strong>Background:<\/strong><\/h2>\n<p>Gastric neuroendocrine tumors (gNETs) are uncommon neoplasms arising from enterochromaffin-like cells, representing a distinct subset of gastric malignancies, with challenging clinical management.<\/p>\n<h2><strong>Aims:<\/strong><\/h2>\n<p>To analyse the classification, treatment indication, and survival of patients diagnosed with gNETs.<\/p>\n<h2><strong>Methods:<\/strong><\/h2>\n<p>We retrospectively analyzed patients diagnosed with gNETs between 2009 and 2025 at a high-volume tertiary center in Brazil. Clinical, pathological, and treatment data were reviewed, and tumors were classified according to World Health Organization and clinicopathological criteria into Types I, II, and III.<\/p>\n<h2><strong>Results:<\/strong><\/h2>\n<p>Of the 75 patients included, 53 (70.7%) were classified as Type I, 5 (6.7%) as Type II, and 17 (22.6%) as Type III. Treatment included surgery in 25 patients (33.3%) and endoscopic resection in 50 (66.7%). Type I tumors predominated in females (p&lt;0.001), were frequently multifocal (p&lt;0.001), associated with higher body mass index (p=0.002), and were mainly managed endoscopically (p=0.008). Type II tumors were rare and associated with multiple endocrine neoplasia Type 1, while Type III tumors were predominantly male, larger, high-grade (G3), and frequently metastatic, requiring surgical resection and palliative therapy. Among the 25 surgically treated patients, most were men (52%) and included 12 patients (48.0%) with Type I, 3 (12.0%) with Type II, and 10 (40.0%) with Type III tumors. Survival analysis showed significantly worse outcomes for Type III and G3 tumors. Multivariable analysis identified advanced age (hazards ratio 4.11; 95% confidence interval (95%CI): 1.14\u201314.80; p=0.030) and tumor, lymph node, metastasis (TNM) stage III\/IV (HR 5.42; 95%CI: 1.26\u201323.26; p=0.023) as independent predictors of poorer survival.<\/p>\n<h2><strong>Conclusions:<\/strong><\/h2>\n<p>gNETs exhibit heterogeneous clinical behavior, with Type I tumors predominating in the Brazilian population. Tumor type, grade, and TNM stage are critical determinants of prognosis and should guide individualized treatment strategies.<\/p>","protected":false},"excerpt":{"rendered":"<p>Background: Gastric neuroendocrine tumors (gNETs) are uncommon neoplasms arising from enterochromaffin-like cells, representing a distinct subset of gastric malignancies, with challenging clinical management. Aims: To analyse the classification, treatment indication, and survival of patients diagnosed with gNETs. Methods: We retrospectively analyzed patients diagnosed with gNETs between 2009 and 2025 at a high-volume tertiary center in [&hellip;]<\/p>","protected":false},"author":14,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[9],"tags":[169,50,1282,147,128],"class_list":["post-6433","post","type-post","status-publish","format-standard","hentry","category-original-article","tag-endoscopy","tag-gastrectomy","tag-neuroendocrine-tumors","tag-stomach-neoplasms","tag-survival-analysis"],"acf":[],"modified_by":"Rodrigo","_links":{"self":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts\/6433","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/comments?post=6433"}],"version-history":[{"count":2,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts\/6433\/revisions"}],"predecessor-version":[{"id":6436,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/posts\/6433\/revisions\/6436"}],"wp:attachment":[{"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/media?parent=6433"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/categories?post=6433"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistaabcd.org.br\/pt-br\/wp-json\/wp\/v2\/tags?post=6433"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}