Dyspepsia is a set of symptoms of the upper abdomen and has a prevalence of 10–45% of the population with different etiological possibilities, including celiac disease.
The aim of this study was to evaluate the prevalence of celiac disease in patients with a clinical diagnosis of dyspeptic syndrome.
This is an observational research, based on a review of medical records of patients treated for uninvestigated dyspepsia. Patients over 18 years of age, with uninvestigated dyspepsia, and who had upper endoscopy, total immunoglobulin A (IgA), and antitissue transglutaminase IgA were included. Those with diarrhea, constipation, malabsorption, refractory lactose intolerance, or who presented extraintestinal signs or symptoms suggestive of celiac disease were excluded.
The initial sample was 1,802 records and the final 200 patients. Considering the total sample, the average age was 45.13 years and the female sex was predominant. Symptoms associated with gluten were reported in 6% of the patients. The antitissue transglutaminase IgA was positive in 1.5% of the patients. Considering the sample of 100 patients, the diagnosis of celiac disease had a prevalence of 3%.
The prevalence of celiac disease in patients with a clinical diagnosis of dyspeptic syndrome was 3%.
Celiac disease is an enteropathy characterized by gluten sensitivity and broad clinical aspect. Has a multifactorial cause and depends on genetic, immunological and environmental factors for its development. The genetic influence is given mostly by the human leukocyte antigens HLA DQ2 and DQ8.
To evaluate the prevalence of human leukocyte antigens DQ2 and DQ8 in three different groups: patients with celiac disease, first-degree relatives and the general population.
Retrospective analysis that evaluated serologic and endoscopic data of 74 patients with celiac disease and 109 non-celiac, which were subdivided into two subgroups: non-celiac who had first-degree relatives with celiac and non-celiac who did not. All patients underwent laboratory examination for screening genetic sensitivity given by HLA DQ2 and HLA DQ8 by.
The presence of HLA DQ2 and DQ8 was identified in 98,4% of 74 celiac patients, of which 79,7% had only HLA DQ2; 8,1% had only HLA DQ8 and 10,8% had both antigens histocompatibility. In the group of relatives of celiac patients, were included 29 patients; among them, 89,6% had HLA DQ2 and/or DQ8; 76% only the HLA DQ2, 10,3% only HLA DQ8 and 3,4% presented both human leukocyte antigens (HLA).
HLA DQ2/DQ8 was present in 98,4% of celiac patients; 89,6% relatives of celiac family and in 55,4% of people from the general population without family celiac.
Desenvolvido por Surya MKT