21 Oct, 2019

EFFECT OF COPAIBA OIL IN INTESTINAL MUCOSA OF RATS SUBMITTED TO HYPOVOLEMIC SHOCK 

Renan Kleber Costa TEIXEIRA
Felipe Lobato da Silva COSTA
Faustino Chaves CALVO
Deivid Ramos dos SANTOS
Edson Yuzur YASOJIMA
Marcus Vinicius Henriques BRITO
DOI: 10.1590/0102-672020190001e1451
Share this article

Background:

Hypovolemic shock is a common disease in polytrauma patients and may develop ischemia in various organs, increasing morbidity and mortality. The bowel is usually most affected by this condition.

Aim:

To evaluate the effects of copaiba oil on the intestinal mucosa’s injury of rats submitted to hypovolemic shock.

Method:

Fifteen rats were divided into three groups: sham - simulated surgery; ischemia - animals submitted to hypovolemic shock; and copaiba - animals submitted to hypovolemic shock previously treated with copaiba oil. Mean blood pressure, arterial blood gas after shock induction, degree of intestinal lesion and villus length were evaluated.

Results:

The sham presented the lowest values of lactate and PaCO2 and the highest values of mean arterial pressure, pH and bicarbonate in relation to the other groups. The degree of mesenteric lesion was zero in the sham group; 3.00±1.00 in the ischemia group; and 3.00±0.71 in the copaiba group. The villus length was 173.60±8.42 in the sham, 142.77±8.33 in the ischemia and 143.01±9.57 in the copaiba group. There was a significant difference between the sham and the other groups (p<0.05); however, there not significant difference between groups Ischemia and copaiba.

Conclusion:

Administration of copaiba oil did not reduce the intestinal mucosa lesion of rats after hypovolemic shock.


. . .
Indexed in:
Follow us!
ABCD – BRAZILIAN ARCHIVES OF DIGESTIVE SURGERY is a periodic with a single annual volume in continuous publication, official organ of the Brazilian College of Digestive Surgery - CBCD.

Developed by Surya MKT