09 Dec, 2019

EFFICACY OF CURCUMA LONGA IN THE TREATMENT OF DIVERSION COLITIS IN RATS

Arthur Medeiros LIMA
Carlos Eduardo Costa NASCIMENTO
Carlos Henrique Marques dos SANTOS
Doroty Mesquita DOURADO
Gabriel Elias Cardoso SIQUEIRA
Giovana Maria RIGO
Lauren Umpierre BERNARDI
Paulo Otávio Souza LEONEL
Rosemary MATIAS
Vitor Caldas FERREIRA
Vitor Cruz Rosa Pires de SOUZA
DOI: 10.1590/0102-672020190001e1456
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Background:

Diversion colitis is still very common in our country, since the stoma creation is a common practice especially in situations of trauma. needing treatment for this condition.

Aim:

To evaluate the therapeutic effect of rectal infusion of Curcuma longa (turmeric) in the excluded intestinal segment of rats.

Method:

Eighteen Wistar rats were used and submitted to colostomy: control group (n=8) under rectal saline infusion and group CL, receiving intra-rectal infusion of Curcuma longa extract (n=10). After 21 days of treatment they were submitted to euthanasia; the intestinal segment excluded from intestinal transit was resected and sent to histopathological evaluation, classifying the degree of inflammation and of vascular congestion.

Results:

The average of inflammation was 2.7 in the control group vs. 2.6 in the CL group (p=0.3125), while the mean vascular congestion was 2.3 and 2.1, respectively, in the control and CL groups (p=0.1642).

Conclusion:

Intra-rectal infusion of Curcuma longa extract was not able to minimize the inflammatory process or vascular congestion in the diversion colitis of rats subjected to colostomy.


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