14 May, 2021

IS THERE CORRELATION BETWEEN HUMAN PAPILLOMAVIRUS (HPV) AND ESOPHAGEAL EPIDERMOID CARCINOMA?

Luiz Filipe Alkamin WOELLNER
Juliano Smaniotto de MEDEIROS
Carmen Australia Paredes Marcondes RIBAS
Paulo Afonso Nunes NASSIF
Jurandir Marcondes RIBAS-FILHO
Ana Cristina Lira SOBRAL
Bruno Luiz ARIEDE
Debora Azeredo Pacheco Dias DA COSTA
Osvaldo MALAFAIA
DOI: 10.1590/0102-672020200002e1528
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Background:

Currently, persistent human papillomavirus (HPV) infection has been related in some geographic regions as a risk factor for esophageal squamous cell carcinoma. It results in the immunoexpression of the p16 protein, which has been used as marker of the oncogenic lineage by this etiological agent.

Aim:

To correlate epidemiological aspects of esophageal squamous cell carcinoma with the prevalence of HPV infection.

Methods:

Fifty-eight cases were analyzed and submitted to histopathological and immunohistochemical analysis by p16.

Results:

Of the 58 cases evaluated, 40 were men and 18 women, with a mean age of 63.2 years. p16 immunoexpression was positive in 46.55%.

Conclusion:

The prevalence of HPV infection is high in esophageal squamous cell carcinoma presenting in almost half of the cases (46.55%), without gender differentiation.


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