Revista ABCd (São Paulo). 16 Feb, 2018

PROGNOSTIC VALUE OF CARCINOEMBRYONIC ANTIGEN LEVELS IN TRANSOPERATIVE PERITONEAL LAVAGE IN PATIENTS WITH GASTRIC CANCER

Letícia Biscaino ALVES
Maria Teresa TSUKAZAN
Ana Elisa SERAFIM
Rolando MENDOZA
Alexandre Vontobel PADOIN
Plínio Carlos BAÚ
Luis Fernando MOREIRA
DOI: 10.1590/0102-672020180001e1358

Background:

The carcinoembryonic antigen level in peritoneal lavage has been showing to be a reliable prognostic factor in gastric cancer.

Aim:

To identify any association between carcinoembryonic antigen level in peritoneal lavage, in gastric cancer patients, with mortality, peritoneal recurrence, tumor relapse or other prognostic factors.

Methods:

In total, 30 patients (22 men, 8 women; median age 66 years) with resectable gastric cancer (mainly stage III and IV) were studied. Carcinoembryonic antigen level in peritoneal lavage was detected at operation by immunocytochemical method and a level over 210 ng/g of protein was considered as positive.

Results:

There were detected 10 positive cases (33.3%) of plCEA levels. These levels were associated with mortality, RR: 2.1 (p=0.018); peritoneal recurrence, OR: 9.0 (p=0.015); and relapse or gastric cancer progression, OR: 27.0 (p=0.001).

Conclusion:

Increased levels of plCEA fairly predicts mortality, peritoneal recurrence tumor relapse or cancer progression.


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