05 Jan, 2022

PROTOCOL FOR LIVER TRANSPLANTATION IN HILAR CHOLANGIOCARCINOMA

Lucas ERNANI
Rodrigo Bronze de MARTINO
Wellington ANDRAUS
Eduardo de Souza Martins FERNANDES
Felipe Pedreira Tavares de MELLO
Ronaldo ANDRADE
Leandro Savattone PIMENTEL
Luciana Bertocco de Paiva HADDAD
Fabricio Ferreira COELHO
Paulo HERMAN
Luiz Augusto Carneiro D’ALBUQUERQUE
DOI: 10.1590/0102-672020210002e1618
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Background:

Hilar cholangiocarcinoma represents more than half of all cholangiocarcinoma cases, having poor prognosis and presenting a median overall survival after diagnosis of 12-24 months. In patients who have unresectable tumors with a better prognosis, the proposal to perform liver transplantation emerged for expanding the possibility of free margins by performing total hepatectomy.

Aim:

To provide a Brazilian protocol for liver transplantation in patients with hilar cholangiocarcinoma.

Method:

The protocol was carried out by two Brazilian institutions which perform a large volume of resections and liver transplantations, based on the study carried out at the Mayo Clinic. The elaboration of the protocol was conducted in four stages.

Result:

A protocol proposal for this disease is presented, which needs to be validated for clinical use.

Conclusion:

The development of a liver transplantation protocol for cholangiocarcinoma aims not only to standardize the treatment, but also enable a better assessment of the surgical results in the future.


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