25 Sep, 2018

THE CANONICAL WNT PATHWAY IN GASTRIC CARCINOMA 

Levindo Alves de OLIVEIRA
Celina Tizuko Fujiyama OSHIMA
Pedro Augusto SOFFNER
Marcelo de Souza SILVA
Rodrigo Rego LINS
Andréa Cristina de Moraes MALINVERNI
Jaques WAISBERG
DOI: 10.1590/0102-672020180001e1414
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Background :

It is believed that the Wnt pathway is one of the most important signaling involved in gastric carcinogenesis.

Aim

: To analyze the protein expression of canonical and non-canonical Wnt pathways in gastric carcinoma.

Method

: The immunohistochemistry was performed in 72 specimens of gastric carcinomas for evaluating the expression of Wnt-5a, FZD5, GSK3β, axin, CK1, ubiquitin, cyclin D1 and c-myc.

Results

: There were significant differences for cytoplasm and nucleus ubiquitin for moderately and well differentiated tumors (p=0.03) and for those of the intestinal type of the Lauren classification (p=0.03). The absence of c-myc was related to Lauren’s intestinal tumors (p=0.03). Expression of CK1 in the cytoplasm was related to compromised margin (p=0.03). Expression of cyclin D1 protein was more intense in male patients (p=0.03) There was no relation of the positive or negative expression of the Wnt-5a, FZD5, GSK3 and Axin with any clinicopathological variables.

Conclusion:

The canonical WNT pathway is involved in gastric carcinoma.


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