10 nov, 2015

IMMUNOLOGICAL EVALUATION OF PATIENTS WITH TYPE 2 DIABETES MELLITUS SUBMITTED TO METABOLIC SURGERY

Marisa de Carvalho BORGES
Guilherme Azevedo TERRA
Tharsus Dias TAKEUTI
Betânia Maria RIBEIRO
Alex Augusto SILVA
Júverson Alves TERRA-JÚNIOR
Virmondes RODRIGUES-JÚNIOR
Eduardo CREMA
DOI: 10.1590/S0102-6720201500040012
Compartilhe esse artigo

Background:

Immunological and inflammatory mechanisms play a key role in the development and progression of type 2 diabetes mellitus.

Aim:

To raise the hypothesis that alterations in immunological parameters occur after duodenojejunal bypass surgery combined with ileal interposition without gastrectomy, and influences the insulin metabolism of betacells.

Methods:

Seventeen patients with type 2 diabetes mellitus under clinical management were submitted to surgery and blood samples were collected before and six months after surgery for evaluation of the serum profile of proinflammatory (IFN-γ, TNF-α, IL-17A) and anti-inflammatory cytokines (IL-4, IL-10). In addition, anthropometric measures, glucose levels and insulin use were evaluated in each patient.

Results:

No changes in the expression pattern of proinflammatory cytokines were observed before and after surgery. In contrast, there was a significant decrease in IL-10 expression, which coincided with a reduction in the daily insulin dose, glycemic index, and BMI of the patients. Early presentation of food to the ileum may have induced the production of incretins such as GLP-1 and PYY which, together with glycemic control, contributed to weight loss, diabetes remission and the consequent good surgical prognosis of these patients. In addition, the control of metabolic syndrome was responsible for the reduction of IL-10 expression in these patients.

Conclusion:

These findings suggest the presence of low-grade inflammation in these patients during the postoperative period, certainly as a result of adequate glycemic control and absence of obesity, contributing to a good outcome of surgery.


. . .
Indexado em:
SIGA-NOS!
ABCD – ARQUIVOS BRASILEIROS de CIRURGIA DIGESTIVA é periódico com um único volume anual em sistema de publicação continua, órgão oficial do Colégio Brasileiro de Cirurgia Digestiva – CBCD.

Desenvolvido por Surya MKT