Revista ABCd (São Paulo). 10 jan, 2017

Angiolymphatic invasion as a prognostic fator in resected N0 pancreatic adenocarcinoma

Ricardo Vitor Silva de ALMEIDA
Adhemar Monteiro PACHECO-JR
Rodrigo Altenfelder SILVA
André de MORICZ
Tércio de CAMPOS
DOI: 10.1590/0102-6720201700010012

Background:

Pancreatic adenocarcinoma remains one of the worst digestive cancers. Surgical resection is the main target when treating a patient with curative intent.

Aim:

To assess angiolymphatic invasion as a prognostic factor in resected pN0 pancreatic cancer.

Methods:

Thirty-eight patients were submitted to pancreatoduodenectomy due to head pancreatic cancer. Tumor size, margins, lymph nodes, pTNM staging, angiolymphatic and perineural invasion were described in the pathologists' reports.

Results:

Most patients were female. Overall median survival was 13 months. Gemcitabine was the regimen of choice for chemotherapy in selected patients; however, it did not improve overall survival. pR0 resection had better survival compared with pR1. Within the pN0 group, survival was significantly better in patients without angiolymphatic invasion.

Conclusion:

Angiolymphatic invasion in N0 pancreatoduodenectomy can be demonstrated by the Hematoxylin-Eosin stain and may predict a poor prognosis factor for those patients.


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ABCD – BRAZILIAN ARCHIVES OF DIGESTIVE SURGERY is a periodic with a single annual volume in continuous publication, official organ of the Brazilian College of Digestive Surgery - CBCD. Technical manager: Dr. Francisco Tustumi | CRM: 157311 | RQE: 77151 - Cirurgia do Aparelho Digestivo

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