01 nov, 2016

GLP-2: A POORLY UNDERSTOOD MEDIATOR ENROLLED IN VARIOUS BARIATRIC/METABOLIC SURGERY-RELATED PATHOPHYSIOLOGIC MECHANISMS

Everton CAZZO
Martinho Antonio GESTIC
Murillo Pimentel UTRINI
Felipe David Mendonça CHAIM
Bruno GELONEZE
José Carlos PAREJA
Elinton Adami CHAIM
Daniéla Oliveira MAGRO
DOI: 10.1590/0102-6720201600040014
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Introduction:

Glucagon-like peptide-2 (GLP-2) is a gastrointestinal hormone whose effects are predominantly trophic on the intestinal mucosa.

Aim:

Critically evaluate the current literature on the influence of bariatric/metabolic surgery on the levels of GLP-2 and its potential clinical implications.

Method

s: Narrative review through online research on the databases Medline and Lilacs. There were six prospective human studies, two cross-sectional human studies, and three experimental animal studies selected.

Results:

There is evidence demonstrating significant increase in the levels of GLP-2 following gastric bypass, Scopinaro operation, and sleeve gastrectomy. There are no differences between gastric bypass and sleeve gastrectomy in regards to the increase in the GLP-2 levels. There is no correlation between the postoperative levels of GLP-2 and the occurrence of adequate or insufficient postoperative weight loss.

Conclusion:

GLP-2 plays significant roles on the regulation of nutrient absorption, permeability of gut mucosa, control of bone resorption, and regulation of satiety. The overall impact of these effects potentially exerts a significant adaptive or compensatory effect within the context of varied bariatric surgical techniques.


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Indexado em:
SIGA-NOS!
ABCD – ARQUIVOS BRASILEIROS de CIRURGIA DIGESTIVA é periódico com um único volume anual em sistema de publicação continua, órgão oficial do Colégio Brasileiro de Cirurgia Digestiva – CBCD.

Desenvolvido por Surya MKT